drugs

  • AIDS drugs: when resistance is futile

    In nearly every conversation I’ve had with Affecteds who are experimenting with ways to reduce the toxicity of antiretroviral (ARV) regimens, questions about “AIDS drug resistance” comes up. Resistance is often raised as a boogeyman in research trials of monotherapy and intermittent treatment options. While drug resistance—especially bacterial antibiotic resistance to staphylococcus or tuberculosis, for example—is increasingly a problem in modern medicine, one is unlikely to hear drug resistance discussed quite the way it is with AIDS. No other pathogen is described as “sneaky”, “clever”, or more mutable than HIV, despite the fact that retroviruses do not even meet most definitions for being a living entity, let alone have a brain.

  • AIDS drug guidelines: Stop the nukes!

    Stop the nukes! No, not nuclear weapons. Well, yes, those too, but today I’m writing about the increase in reports I’m seeing from the AIDS drug medical literature calling for an end to the use of nucleoside(tide) reverse transcriptase inhibitors (NRTIs), not-so-ironically referred to as “nukes”. As I have written previously, there have been rumblings from clinicians and researchers in the medical literature since at least 2010 to get rid of the NRTI class of antiretroviral drugs entirely from treatment guidelines.

    Unfortunately, it is unlikely that this change will occur at anything comparable to the speed with which AZT and other poison pills were “fast-tracked” to market more than 25 years ago.

  • Quitting drugs is not enough

      Some folks who have read my story about quitting AIDS drugs and nearly two dozen other prescription drugs seem to think I attribute my improved health to that choice alone. It isn’t that simple. There is no doubt in my mind that taking so many prescription drugs, even under the care of physicians,…

  • Checking in: quit ARV drugs again

    Gawd forbid this period of inactivity be mistaken as some sort of ill omen. What I can say is that I’m alive and doing well by most measures that matter. I am struggling with fatigue, and depression, which may help explain my absence online.

    I quit the low-dose darunavir monotherapy on May 29, almost exactly one year after I had restarted ARVs. I am satisfied with, if not excited about the “numbers”, which I will update in a future post, along with additional news about my health and medical status.

  • Rethinking MAF 314

    One of the most vexing issues I’ve had to deal with since I started exploring alternatives to ART (antiretroviral therapy) for keeping my immune system as healthy as I can, is my inability to abide by some of the most basic rules of scientific research. I’m not beating myself up too much for this…

  • The end of AZT?

    As I spend time this week with one of my dearest friends, a man who has been HIV-positive since at least 1987, and who has been on ARVs almost continuously since 1990, I am reminded that Affecteds have always had the option to consider alternatives to conventional pharmaceutical treatment. Last night we recalled some…

  • Save Rico

    I am getting sicker by the minute, after reading a story of horrific abuse of power by the medical establishment that broke early this morning. Tragedy has stricken a newborn infant, being held in the hospital affiliated with the Mayo Clinic, in Rochester, Minnesota. A court ordered that Rico Martinez Nagel be removed from…

  • HIV and my dear friend

    I mentioned in my last post that I frequently get messages from people, asking about something I’ve shared, or sharing their own story. A few days ago, I received just such an email from a person I’ve never met, but who I’ve come to know fairly well online, and we continued the exchange through…

  • Join me on my journey

    Today is Valentine’s Day, and I am sitting in a motel room in Wichita, Kansas, pondering: how do I dare ask friends, family and strangers to give me money so I can continue to experiment with alternative health therapies? The painful answer is:  I have no choice, but to try. I left KC at…

  • Just another tease

    Here’s another short outtake from the pre-show walkthrough that John Grosso and I had in a G+ Hangout On Air (HOA) earlier this week for tomorrow evening’s Rainbow Show. Live stream begins at 7 pm CST.     Please drop in to view the show live, and ask questions via the comment stream on YouTube or Google+….