clinical research

reports and studies about HIV, AIDS and anti-retroviral drugs and their effects

Reduce AIDS drug toxicity and side effects

Reduce AIDS drug toxicity and side effects

I embarked on my third course of ARVs since 1998. For ten of the sixteen years I have been HIV-positive, I was able to manage well enough without ARVs and I continue to believe there is no reason for otherwise healthy HIV-positive—let alone negative—gay men to take these drugs. To those who want to wave a recent study about the benefits of early intervention in my face, I would ask them why they put so much faith in a science that has utterly failed us to date.

The truth about Truvada: PrEP won’t stop AIDS

The truth about Truvada: PrEP won’t stop AIDS

I’m willing to grant that gay men are entitled to use PrEP… provided they have access to all the information they need to make an informed decision. Informed consent has been a hallmark of the HIV and AIDS research and prevention efforts for three decades, and that shouldn’t be waived for the campaign favoring PrEP.

Gay men deserve to know that all the claims for Truvada reducing the risk of acquiring HIV-positivity  are based on trials—funded by Gilead—that emphasized the importance of using condoms…

Glia cell in cell culture from neonatal mouse brain, green: glia cell, red peroxisome (Courtesy of Max-Planck-Institute for experimental medicine, Goettingen, Germany)

Is the bubble about to burst?

Call it intuition, but something tells me that it is about time for science to be turned on its head for being wrong.  Again. Recently, published reports from various scientific fields offer new insight about possible ways the human immune system wards off disease, specifically those conditions blamed on viruses, such as AIDS and…

Pharmaceutical solutions to AIDS are not enough

A recent phone conversation with a friend is helping me to continue to refine what I want to focus on as an AIDS dissident activist. In a passionate outburst that revealed a new side of his character, he blurted out his dismay that our society in general and our gay community in particular seems to be willing to settle for a solution to AIDS that relies exclusively on drugs from the pharmaceutical industry.

Dr. Jacques Leibowitch: 4 days a week is enough!

Dr. Jacques Leibowitch: 4 days a week is enough!

In the simplest possible summation, Leibowitch has been treating HIV-positive patients with traditional ARV cocktails, called HAART. Where he leaves the path of traditional treatment guidelines is that once a patient is “stabilised”—meaning they have achieved respectably high CD4 counts, and their viral load is undetectable for six months—Leibowitch starts reducing the number of days per week that a patient takes these drugs, to as little as twice per week.

Higher CD4 count increases risk of ARV adverse effects

Higher CD4 count increases risk of ARV adverse effects

Each patient fell into one of three groups: <350 CD4 cells/muL; 351-499; and >500. This last group would be considered “normal” according to AIDS.gov, which lists the range for CD4 counts as 500-1000. Yet, according to this study, this group of so-called “healthy” patients were almost one and a half times more likely to experience a drug-related adverse effect.

The report reinforces another point that I find I must continue to drive home over and over again, and that is the definition of “low CD4 counts”.

Borg ship

AIDS drugs: when resistance is futile

In nearly every conversation I’ve had with Affecteds who are experimenting with ways to reduce the toxicity of antiretroviral (ARV) regimens, questions about “AIDS drug resistance” comes up. Resistance is often raised as a boogeyman in research trials of monotherapy and intermittent treatment options. While drug resistance—especially bacterial antibiotic resistance to staphylococcus or tuberculosis, for example—is increasingly a problem in modern medicine, one is unlikely to hear drug resistance discussed quite the way it is with AIDS. No other pathogen is described as “sneaky”, “clever”, or more mutable than HIV, despite the fact that retroviruses do not even meet most definitions for being a living entity, let alone have a brain.

skeleton examining a pill

On darunavir again

I am dumping a lot of summary information here, without getting into details, but I need to start somewhere. When I zoom out and look at the big picture, it is clear that I am still a long way from being a “healthy” person, and frankly, I no longer expect to become one. The goal now is to mange chronic disease and maintain as good a quality of life as I possibly can.

Homemade yogurt

Rethinking MAF 314

One of the most vexing issues I’ve had to deal with since I started exploring alternatives to ART (antiretroviral therapy) for keeping my immune system as healthy as I can, is my inability to abide by some of the most basic rules of scientific research. I’m not beating myself up too much for this…